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Curbing the burden of lung cancer
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 228-232 doi: 10.1007/s11684-016-0447-x
Lung cancer contributes substantially to the global burden of disease and healthcare costs. New screening modalities using low-dose computerized tomography are promising tools for early detection leading to curative surgery. However, the screening and follow-up diagnostic procedures of these techniques may be costly. Focusing on prevention is an important factor to reduce the burden of screening, treatment, and lung cancer deaths. The International Agency for Research on Cancer has identified several lung carcinogens, which we believe can be considered actionable when developing prevention strategies. To curb the societal burden of lung cancer, healthcare resources need to be focused on early detection and screening and on mitigating exposure(s) of a person to known lung carcinogens, such as active tobacco smoking, household air pollution (HAP), and outdoor air pollution. Evidence has also suggested that these known lung carcinogens may be associated with genetic predispositions, supporting the hypothesis that lung cancers attributed to differing exposures may have developed from unique underlying genetic mechanisms attributed to the exposure of interest. For instance, smoking-attributed lung cancer involves novel genetic markers of risk compared with HAP-attributed lung cancer. Therefore, genetic risk markers may be used in risk stratification to identify subpopulations that are at a higher risk for developing lung cancer attributed to a given exposure. Such targeted prevention strategies suggest that precision prevention strategies may be possible in the future; however, much work is needed to determine whether these strategies will be viable.
Guobin SHAN , Rajeshwar D. TYAGI , Rao Y. SURAMPALLI , Tian C. ZHANG
《环境科学与工程前沿(英文)》 2009年 第3卷 第3期 页码 249-264 doi: 10.1007/s11783-009-0029-0
关键词: nanomaterials industrial agricultural nonpoint source pollution environmental burden reduction
Xiaolong SONG,Jianxin YANG,Bin LU,Bo LI,Guangyuan ZENG
《环境科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 580-588 doi: 10.1007/s11783-013-0599-8
关键词: copper production environmental burden life cycle assessment refined copper
The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes
Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang
《医学前沿(英文)》 2020年 第14卷 第1期 页码 1-7 doi: 10.1007/s11684-019-0733-5
关键词: molecular epidemiology norovirus disease burden genotype China
LI Wei,HU Mengze
《环境科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 316-328 doi: 10.1007/s11783-014-0625-5
关键词: environmental finance policy integrated mechanism phased evolution implementation progress financial institution environmental management
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
《医学前沿(英文)》 2019年 第13卷 第1期 页码 32-44 doi: 10.1007/s11684-018-0678-0
Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.
关键词: immune checkpoint companion diagnosis PD-L1 tumor mutation burden immune score
Trends of environmental accidents and impact factors in China
Pengli XUE, Weihua ZENG
《环境科学与工程前沿(英文)》 2011年 第5卷 第2期 页码 266-276 doi: 10.1007/s11783-010-0267-1
关键词: environmental accidents spatial and temporal trends environmental risk
DONG Hongwei
《环境科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 434-442 doi: 10.1007/s11783-007-0069-2
关键词: law-abiding punishment environmental protection law-breaking enterprise
Chaoyang FU,Wangfeng LI
《环境科学与工程前沿(英文)》 2015年 第9卷 第2期 页码 310-316 doi: 10.1007/s11783-014-0658-9
关键词: environmental policy distributed environment policy distributed parameter model lumped parameter model
Reducing environmental impacts through socioeconomic transitions: critical review and prospects
《环境科学与工程前沿(英文)》 2023年 第17卷 第2期 doi: 10.1007/s11783-023-1624-1
● Reducing environmental impacts through socioeconomic structural transitions.
关键词: Environmental pressures Environmental impacts Nexus Supply chains Trade Coupled systems
Hydrogel photocatalysts for efficient energy conversion and environmental treatment
《能源前沿(英文)》 2021年 第15卷 第3期 页码 577-595 doi: 10.1007/s11708-021-0756-x
关键词: hydrogel photocatalysts energy conversion environmental treatment
NewIndustrial Revolution and Environmental Protection
Qian Yi
《工程管理前沿(英文)》 2014年 第1卷 第1期 页码 71-75 doi: 10.15302/J-FEM-2014011
关键词: industrial ecology new industrial revolution environmental protection cleaner production circular economy
Addressing the environmental risk of persistent organic pollutants in China
Bin WANG, Jun HUANG, Shubo DENG, Xiaoling YANG, Gang YU
《环境科学与工程前沿(英文)》 2012年 第6卷 第1期 页码 2-16 doi: 10.1007/s11783-011-0370-y
关键词: persistent organic pollutant (POPs) environmental risk assessment inventory environmental monitoring fugacity model emerging POPs
Insight of chemical environmental risk and its management from the vinyl chloride accident
《环境科学与工程前沿(英文)》 2023年 第17卷 第4期 doi: 10.1007/s11783-023-1652-x
关键词: Vinyl chloride Combustion Chemical safety management Environmental risk Emerging contaminants
标题 作者 时间 类型 操作
Nanomaterials for environmental burden reduction, waste treatment, and nonpoint source pollution control
Guobin SHAN , Rajeshwar D. TYAGI , Rao Y. SURAMPALLI , Tian C. ZHANG
期刊论文
Identification and assessment of environmental burdens of Chinese copper production from a life cycle
Xiaolong SONG,Jianxin YANG,Bin LU,Bo LI,Guangyuan ZENG
期刊论文
The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes
Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang
期刊论文
An overview of the environmental finance policies in China: retrofitting an integrated mechanism forenvironmental management
LI Wei,HU Mengze
期刊论文
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
期刊论文
Why does environmental compliance cost more than penalty?—A legal analysis on environmental acts of enterprises in China
DONG Hongwei
期刊论文
Analysis of the current situation of environmental policy of China and establishment of distributed environmental
Chaoyang FU,Wangfeng LI
期刊论文
Reducing environmental impacts through socioeconomic transitions: critical review and prospects
期刊论文
Addressing the environmental risk of persistent organic pollutants in China
Bin WANG, Jun HUANG, Shubo DENG, Xiaoling YANG, Gang YU
期刊论文